Antioxidants in an antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to new research published online in April in the American Journal of Respiratory and Critical Care Medicine. July 2, 2018, American Thoracic Society, see article.

Scott D. Sagel, MD, PhD, the Director of the University of Colorado Cystic Fibrosis Center, reports a 50 percent reduced risk of time to the first exacerbation requiring antibiotics in those receiving the antioxidant-enriched supplement during the 16-week multi-center, randomized, controlled clinical study funded by the Cystic Fibrosis Foundation.

Chronic infection and inflammation increase reactive oxygen species and fat-soluble vitamin malabsorption reduce systemic antioxidants in cystic fibrosis. “Improving antioxidant status in CF is an important clinical goal and may have a positive effect on health,” Dr. Sagel said.

“While the antioxidant supplement did not appear to exert sustained anti-inflammatory effects, we believe its effect on time to first pulmonary exacerbation was significant and clinically meaningful,” Dr. Sagel said, adding that the improvement in antioxidant status alone may justify its use. “Developing safe and effective anti-inflammatory treatments remains a key priority of the CF community” reports The Science Daily.  The antioxidant supplement was safe and well tolerated.

DEKAs products, and specifically DEKAs Plus Softgels, has a similar composition and antioxidant profile to the antioxidant supplement investigated in this clinical trial. DEKAs vitamins contain Vitamin A, C, D, E, K, Thiamin (Vitamin B1), Riboflavin (Vitamin B2),Niacin, Vitamin B6, Folic acid, Vitamin B12, Biotin, Pantothenic Acid, Zinc, Selenium, and Coenzyme Q10 and an absorption enhancing delivery technology.

Clinical trial registration available at www.clinicaltrials.gov, ID NCT01859390.

Sagel SD, Khan U, Jain R, Graff G, Daines CL, Dunitz JM, Borowitz D, Orenstein DM, Abdulhamid I, Noe J, Clancy JP, Slovis B, Rock MJ, McCoy KS, Strausbaugh S, Livingston FR, Papas KA, Shaffer ML., Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis: Randomized, Controlled, Multicenter Trial, Am J Respir Crit Care Med. 2018 Apr 24. doi: 10.1164/rccm.201801-0105OC. [Epub ahead of print]. See full article.

Callion Pharma is introducing dietary supplements for enhanced absorption utilizing a delivery technology that helps patients overcome micronutrient malabsorption and lead healthier lives.

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