Supplemental antioxidants reduce exacerbations in cystic fibrosis

Antioxidants in an antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to new research published online in April in the American Journal of Respiratory and Critical Care Medicine. July 2, 2018, American Thoracic Society, see article.

Scott D. Sagel, MD, PhD, the Director of the University of Colorado Cystic Fibrosis Center, reports a 50 percent reduced risk of time to the first exacerbation requiring antibiotics in those receiving the antioxidant-enriched supplement during the 16-week multi-center, randomized, controlled clinical study funded by the Cystic Fibrosis Foundation.

Chronic infection and inflammation increase reactive oxygen species and fat-soluble vitamin malabsorption reduce systemic antioxidants in cystic fibrosis. “Improving antioxidant status in CF is an important clinical goal and may have a positive effect on health,” Dr. Sagel said.

“While the antioxidant supplement did not appear to exert sustained anti-inflammatory effects, we believe its effect on time to first pulmonary exacerbation was significant and clinically meaningful,” Dr. Sagel said, adding that the improvement in antioxidant status alone may justify its use. “Developing safe and effective anti-inflammatory treatments remains a key priority of the CF community” reports The Science Daily.  The antioxidant supplement was safe and well tolerated.

DEKAs products, and specifically DEKAs Plus Softgels, has a similar composition and antioxidant profile to the antioxidant supplement investigated in this clinical trial. DEKAs vitamins contain Vitamin A, C, D, E, K, Thiamin (Vitamin B1), Riboflavin (Vitamin B2),Niacin, Vitamin B6, Folic acid, Vitamin B12, Biotin, Pantothenic Acid, Zinc, Selenium, and Coenzyme Q10 and an absorption enhancing delivery technology.

Clinical trial registration available at www.clinicaltrials.gov, ID NCT01859390.

Sagel SD, Khan U, Jain R, Graff G, Daines CL, Dunitz JM, Borowitz D, Orenstein DM, Abdulhamid I, Noe J, Clancy JP, Slovis B, Rock MJ, McCoy KS, Strausbaugh S, Livingston FR, Papas KA, Shaffer ML., Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis: Randomized, Controlled, Multicenter Trial, Am J Respir Crit Care Med. 2018 Apr 24. doi: 10.1164/rccm.201801-0105OC. [Epub ahead of print]. See full article.

Callion Pharma is introducing dietary supplements for enhanced absorption utilizing a delivery technology that helps patients overcome micronutrient malabsorption and lead healthier lives.

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DEKAs Bariatric has Higher Amount of Thiamine

DEKAs Bariatric has a higher amount of thiamine than most of the other bariatric vitamins. Thiamine deficiency is an important and under-recognized potential adverse effect related to bariatric surgery that can lead to significant morbidity. This has been noted in a recent Bariatric Times article: Alarming Increase in Malpractice Claims Related to Wernicke’s Encephalopathy Post Bariatric Surgery: An Alert to Monitor for Thiamine Deficiency, BT Online Editor | July 1, 2018, by Eric DeMaria, MD, FACS, FASMBS, and Christa Trigilio-Black, PA-C.

“All healthcare professionals should be aware of the risk factors and symptoms associated with nutritional deficiencies, particularly when treating patients who have had bariatric surgery, to minimize any adverse effects. Early recognition of symptoms is important for all providers caring for this patient population.” warns Texas Medical Liability Trust.

DEKAs Bariatric has 25 mg of thiamine per serving, utilizes clinically tested delivery technology to enhance absorption of fat-soluble vitamins and nutrients, meets ASMBS Integrated Health Guidelines for the Surgical Weight Loss Patient, 2016 update, has been shown to be more effective than a standard multivitamin in maintaining therapeutic levels of clinically relevant vitamins and minerals and was more palatable1.

1Perin J, Prokopowicz G, Furtado M, Papas K, Steele KE. A Randomized Trial of a Novel Chewable Multivitamin and Mineral Supplement Following Roux-en-Y Gastric Bypass. Obes Surg. 2018 Mar 2. doi: 10.1007/s11695-018-3177-0. 

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New Ways to Purchase DEKAs Bariatric

Callion Pharma is pleased to announce additional channels for patients to purchase DEKAs Bariatric, a comprehensive multivitamin and mineral supplement with a clinically proven delivery technology to enhance the absorption of key vitamins and micronutrients. 

Purchase DEKAs Bariatric from Callion Pharma

 

Purchase DEKAs Bariatric from Bariatric Pal

 

Purchase DEKAs Bariatric from a local Pharmacy

We are pleased to report that DEKAs Vitamins can now be drop-shipped via McKesson, so Rite Aid, Target, Walmart and other pharmacies that use McKesson can now stock them (drop ship, #3906096). You may need to ask the pharmacist (not the front clerks) to order them for you as they are considered a specialty item.

 

About Callion Pharma

Callion Pharma is a privately held company that develops and markets advanced nutritional products that maximize the delivery of micronutrients for enhanced absorption. The Callion Pharma team combines expertise in the design, development and commercialization of disease specific products based on science and clinical evidence.

Contact us at contact@callionpharma.com or 423-930-9243, or visit our website https://callionpharma.com.

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DEKAs Bariatric Vitamin Clinical Study

Callion Pharma is pleased to announce the publication of A Randomized Trial of a Novel Chewable Multivitamin and Mineral Supplement Following Roux-en-Y Gastric Bypass, Perin J, Prokopowicz G, Furtado M, Papas K, Steele KE.

A prototype to DEKAs Bariatric has been studied in a randomized controlled clinical trial against the standard bariatric regimen at The Johns Hopkins Center for Bariatric Surgery.

“At 3 months, plasma levels of PTH were lower (p = 0.042), and levels of vitamin D (p = 0.033), thiamine (p = 0.009), and beta-carotene (p = 0.033) were higher in the investigational multivitamin arm compared to those in the standard regimen arm. Patients receiving the investigational multivitamin reported higher taste satisfaction than those receiving the standard regimen (p = 0.035).”

“The investigational multivitamin appears to be more effective than a standard multivitamin in maintaining therapeutic levels of clinically relevant vitamins and minerals, and was more palatable.”

Link to Clinical Study Abstract

 

DEKAs Bariatric is pleasant tasting chewable tablets with an orange-peach flavor that is easy to take on a regular basis. It is easy and simple for all types of bariatric surgeries to take.

Usual Dosages for Types of Surgery Patients:

GB – 1 per day

Sleeve – 1 or 2 per day

RYGB/DS – 2 per day

 

About Callion Pharma

Callion Pharma is a privately held company that develops and markets advanced nutritional products that maximize the delivery of micronutrients for enhanced absorption. The Callion Pharma team combines expertise in the design, development and commercialization of disease specific products based on science and clinical evidence.

Contact us at contact@callionpharma.com or 423-930-9243, or visit our website https://callionpharma.com.

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DEKAs Bariatric Vitamin Now Available

Callion Pharma is pleased to announce the availability of DEKAs Bariatric Vitamin, a multivitamin and mineral supplement formulation developed specifically for the nutritional needs of the bariatric surgery patient.

Bariatric surgery patients often have difficulty absorbing nutrients and need additional supplementation with specific nutrients. DEKAs Bariatric contains a delivery technology to enhance the absorption of these nutrients and meet the American Society of Metabolic and Bariatric Surgery (ASMBS) Integrated Health Guidelines for the Surgical Weight Loss Patient, 2016 update, the most current guidelines for supplementation in bariatric surgery patients. See ASMBS Guidelines.

A prototype formulation has been clinically studied in subjects following Roux-en-Y gastric bypass (RYGB) and shown to be more effective than a standard multivitamin in maintaining therapeutic levels of clinically relevant vitamins and minerals and was more palatable (1).

DEKAs Bariatric is pleasant tasting chewable tablets with an orange-peach flavor that is easy to take on a regular basis. It is easy and simple for all types of bariatric surgeries to take.

Usual Dosages for Types of Surgery Patients:

GB – 1 per day

Sleeve – 1 or 2 per day

RYGB/DS – 2 per day

 

1Perin J, Prokopowicz G, Furtado M, Papas K, Steele KE. A Randomized Trial of a Novel Chewable Multivitamin and Mineral Supplement Following Roux-en-Y Gastric Bypass. Obes Surg. 2018 Mar 2. doi: 10.1007/s11695-018-3177-0. [Epub ahead of print]

About Callion Pharma

Callion Pharma is a privately held company that develops and markets advanced nutritional products that maximize the delivery of micronutrients for enhanced absorption. The Callion Pharma team combines expertise in the design, development and commercialization of disease specific products based on science and clinical evidence.

Contact us at contact@callionpharma.com or 423-930-9243, or visit our website https://callionpharma.com.

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Introducing Aqua-E Concentrate

Callion Pharma is pleased to announce the introduction and availability of Aqua-E Concentrate, a unique, patented, water-soluble vitamin E formulation delivering 75 IU of vitamin E per mL.

Formulated with TPGS, Aqua-E Concentrate contains a clinically proven delivery technology to enhance the absorption of vitamin E in conditions associated with malabsorption.

Aqua-E Concentrate is supplied in a 2oz bottle in a carton containing a graduated dropper.

Aqua-E Concentrate is formulated for scaled dosing based on patient needs, and various dosages are easy to accommodate.  It is odorless and has a neutral taste, so it mixes easily with most beverages, milk, and water, making it easy to administer especially in infants and children. It is also gluten-free with no added flavors or colors, assuring purity.

Aqua-E Concentrate Overview

Aqua-E Concentrate Supplement Facts & Dosage

Professional Resources

About Callion Pharma

Callion Pharma is a privately held company that develops and markets advanced nutritional products that maximize the delivery of micronutrients for enhanced absorption. The Callion Pharma team combines expertise in the design, development and commercialization of disease specific products based on science and clinical evidence.

Contact us at contact@callionpharma.com or 423-930-9243, or visit our website https://callionpharma.com.

 

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