Aqua-E is Water-Soluble Vitamin E Formulated with TPGS for Clinically Proven Enhanced Vitamin E Absorption

Aqua-E® is a unique, patented, water-soluble vitamin E formulation that contains natural tocopherols and tocotrienols. Formulated with TPGS, Aqua-E has been clinically shown to increase absorption of vitamin E in people who have conditions associated with malabsorption.

In use for over 11 years by academic medical centers, Aqua-E has become the standard of care for the dietary management of vitamin E deficiency in conditions of malabsorption.

Microsphere Absorption Technology

Aqua-E utilizes a microsphere absorption technology that micellizes vitamin E to improve absorption, by enclosing the lipophilic portion inside hydrophilic spheres that facilitate the transport and absorption in the body.

Why Choose Aqua-E?

  • It contains the Complete Vitamin E Family
  • It supplies the complete vitamin E family of tocopherols and tocotrienols in a micellized, water-soluble form that is ready for absorption.
  • It is Odorless with Neutral Taste
  • It mixes easily with most beverages and water.
  • It provides Easy Dosage adjustments
  • It is gluten & casein free (GF/CF) and is free of animal products, yeast, wheat, added colors or flavors, sweeteners and salt, and is suitable for vegetarians

The lipophilic interior holds the fat-soluble vitamin E while the hydrophilic exterior facilitates transport and absorption.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Absorption is Supported by Clinical Data

Aqua-E produced a marked and statistically significant increase in the absorption of the gamma-tocopherol form of vitamin E in malabsorbing patients as compared to an oil-based softgel formulation. Aqua-E produces an increase in blood levels (AUC-area under the curve) of the tocopherols that ranged from 2 to 4 times higher than an equal amount of the oil-based vitamin E. Papas K, Kalbfleisch J, Mohon R. Bioavailability of a novel, water-soluble vitamin E formulation in malabsorbing patients. Dig Dis Sci. 2007 Feb;52(2):347-52.

Aqua-E Supplement Facts

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Free of: animal products, yeast, wheat, added colors, flavors, or sweeteners, and salt. Gluten and Casein Free.

20 IU alpha-tocopherol = 1ml of Aqua-E

100 IU alpha-tocopherol = 1 teaspoon Aqua-E (5ml)

200 IU alpha-tocopherol = 2 teaspoons Aqua-E (10ml)

400 IU alpha-tocopherol = 4 teaspoons Aqua-E (20ml)

Aqua-E Dosage

Ages less than 2 yrs: as directed by a healthcare professional

2 yrs and above: 1mL daily or as directed by a healthcare professional

Directions for Use

Aqua-E can be taken directly or mixed with your favorite beverage.

Aqua-E may be taken at any time in a single dose or as directed by your healthcare provider. 

Please consult your healthcare provider concerning dosing recommendations.

How Supplied

8 FL OZ (237mL) Bottle

Storage Instructions

Refrigerate after opening and shake well before each use.


Use under the direction of a healthcare professional.

Consult your healthcare professional if taking anticoagulant medication.

Not suitable as a sole source of nourishment.

Safety sealed for your protection.

Do not use if the seal is broken or missing.

Keep out of reach of children.

To obtain product information or to report a serious adverse event, please contact Callion Pharma at 423-930-9243.
UPC 8 55212 04010 4

Frequently Asked Questions

What is the source of the vitamin E?

The tocopherols are derived from vegetable oils (soy, corn) and the tocotrienols are derived from palm oil. The proteins, which are responsible for allergic reactions, have been removed.

Why do IUs only refer to alpha-tocopherol and not the other forms of Vitamin E included in Aqua-E?

That is the industry standard for reporting alpha-tocopherol – the other forms of vitamin E are not included in the IU total and are reported separately in mgs per ml.

Insurance Information

There is no one answer concerning whether your insurance will cover your Aqua-E.  It depends upon your insurance and your condition.  It may be helpful to ask your healthcare practitioner to submit a Prior Authorization Medical Necessity letter with your insurance carrier explaining why you need to take Aqua-E. Click here to download the Prior Authorization Medical Necessity letter.


Absorption of Vitamin E: Oil and Water Do Not Mix, or Do They?

We are water-based organisms – water makes up more than half of our weight. The blood, the lifeline that carries the nutrients and nourishes all our tissues is water-based. Vitamin E, however, is fat-soluble. Oil and water do not mix. The body has to overcome this problem and micelles are the body’s solution. The fat material is put into these unique tiny spheres with a water-loving (hydrophilic) outer layer and is ferried from the gut across the intestinal wall into the blood stream. To make micelles, two major components are absolutely required: Bile – a yellow-green liquid produced in the liver and secreted into the gut. The bile helps emulsify the fat in our diet and provides components of the outer layer of the micelles. Pancreatic juice, a secretion delivered into the upper part of the small intestine (duodenum), where it aids digestion. In the blood stream vitamin E is transported by lipoproteins, the vehicles that transport lipid materials in our body. These are minute spheres with a water friendly outer layer, which allows them to circulate freely in the blood. They carry vitamin E and other lipids in their lipophilic interior.

Vitamin E Malabsorption: Common, Extremely Serious and Preventable

by Andreas M. Papas, Ph.D., vitamin E researcher and author of The Vitamin E Factor book. It may be hard to believe that in the midst of an abundance of food and a plethora of supplements, many people would develop clinical vitamin E deficiency. A dramatic example is cholestasis, a condition in which excretion of the bile is stopped. Cholestatic children develop very serious and often fatal degenerative neurological diseases due to malabsorption of vitamin E. While serious cholestasis is rare, many other common diseases and physiological conditions cause varying degrees of malabsorption with subclinical deficiency. Unfortunately, vitamin E deficiency may go undetected for decades but the cumulative damage to muscle and nerves is debilitating and irreversible.